Keep in mind: a single extra strength Tylenol is 500mg. A standard dose for a headache is 2 pills, or 1000mg.
Weed gummies come in doses of 1mg to 100mg. 1mg is a microdose people might take for mild pain or stress, while 50+mg is a dose for cancer patients often take. A standard dose for occasional recreational highs is 5mg; they recommend first timers start at 2.5mg.
LD50 compares things by weight, rather than dose. By weight, THC is slightly more toxic than acetaminophen. But in terms of the number of therapeutic doses it takes to kill you, it’s way, way safer.
Yes, I came here for this conversation. What’s the ratio of effective dose to LD50 again, because that’s typically what matters. That’s where cannabis and ethanol are in totally different categories. And how high do you need to get before dying from LSD?
700 to 1000 μg. Full out-of-body experiences. Synesthesia more likely. Religious imagery often strong. Entire loss of rationality, lack of ability to walk or interact in any meaningful way.
1500 μgs+ Experiences may be similar to DMT but extended. Basic body functions are challenging. Vision is consumed by hallucinations. No sense of self remains. Audio hallucinations may be strong. Standard reality no longer applies. Merging with objects likely. No type of rational thought left.
A deadly dose is around 800x higher than that. You wouldn’t be as high as a kite. You’d be as high as Voyager one.
That dose of 16.5mg/kg ld50 is for rats.
Mice is lower at 0.3mg/kg.
There have been no know deaths from humans overdosing on lsd, even when people have taken ridiculously high amounts by mistaking it for cocaine and railing lines of it up their nose.
Sure, a little coma, hypERthermia and light gastric bleeding but nothing a short stint in the hospital didn’t sort em out with no lasting effects.
Keep in mind: a single extra strength Tylenol is 500mg. A standard dose for a headache is 2 pills, or 1000mg.
Weed gummies come in doses of 1mg to 100mg. 1mg is a microdose people might take for mild pain or stress, while 50+mg is a dose for cancer patients often take. A standard dose for occasional recreational highs is 5mg; they recommend first timers start at 2.5mg.
LD50 compares things by weight, rather than dose. By weight, THC is slightly more toxic than acetaminophen. But in terms of the number of therapeutic doses it takes to kill you, it’s way, way safer.
Yes, I came here for this conversation. What’s the ratio of effective dose to LD50 again, because that’s typically what matters. That’s where cannabis and ethanol are in totally different categories. And how high do you need to get before dying from LSD?
16.5 mg is 16500 μg. So a 70kg person would need over 1 million μg.
According to https://www.trippingly.net/lsd/the-lsd-dosage-guide, 25 μg is where visual effects start.
A deadly dose is around 800x higher than that. You wouldn’t be as high as a kite. You’d be as high as Voyager one.
The data about LSD lethality in humans is sparse at best it seems: https://www.healthline.com/health/substance-use/can-you-overdose-on-lsd#risk-of-death
That dose of 16.5mg/kg ld50 is for rats.
Mice is lower at 0.3mg/kg.
There have been no know deaths from humans overdosing on lsd, even when people have taken ridiculously high amounts by mistaking it for cocaine and railing lines of it up their nose.
Sure, a little coma, hypERthermia and light gastric bleeding but nothing a short stint in the hospital didn’t sort em out with no lasting effects.