For my playthrough I chose
Neon Street Rat
It was nice to feel like I had a history somewhere. It doesn’t come up a lot, but when it does it feels satisfying. Especially when questing on Neon. You feel street smart.
Wanted
Kind of mid on this one. I didn’t run into a lot of space combat in my playthrough, so having these guys show up here and there was nice. The bit of story you get is ok but I wish there was more.
Parents
Absolutely fantastic, and it is going to be hard to skip on future playthroughs. Its a bit of a bummer they miss your wedding, but between all the free stuff and the unexpecting places you run into them it is 100% worth it.
Wanted: It's OK. I was expecting more ground attacks rather than ship encounters and it can be a bit challenging at first, but you can generally jump out when first hailed, so it's not too bad. Later it's a useful source of combat opponents.
Alien DNA: I like the buffs and I've never noticed the healing penalty. I suppose I did have trouble keeping a supply of medpacks at the start, but that's not been an issue for a while. Would take again.
Serpent's Embrace: little surprised to see if paint me as an active worshiper rather than someone merely raised in the religion. That said, it's not a big deal, and the buff is nice so long as you're on the move a lot.
In another character:
Empath: All very well if you take care to suck up to Constellation. It gets to be a pain if you do something they don't like, or if you're not sufficiently goody-goody for their strict morality. Took for RP reasons, probably would not take again.
Extrovert: Well, I do tend to travel with a follower in this game, but Constellation are annoying. I'm seriously considering Introvert if I do another character.
Dream Home: Rubbish. You don't pay a mortgage so much as rent by the week. There's no financial pressure and while the house is nice, it's easier to use the Lodge or my ship. Would not take again.
I was also very disappointed with the followers in the game after taking extrovert. They seem so flat compared to fallout 4.
Yeah. I wasn't a huge fan of Fallout 4, but they really knocked it out of the park with the companions. I'd happily take Nick for Deacon or Curie, hell or even Perston along on my adventures, and I'm not really a "follower" sort of player.
Constellation though, there's no one there who I think "I want this person to tag along".