For my playthrough I chose
Neon Street Rat
It was nice to feel like I had a history somewhere. It doesn’t come up a lot, but when it does it feels satisfying. Especially when questing on Neon. You feel street smart.
Wanted
Kind of mid on this one. I didn’t run into a lot of space combat in my playthrough, so having these guys show up here and there was nice. The bit of story you get is ok but I wish there was more.
Parents
Absolutely fantastic, and it is going to be hard to skip on future playthroughs. Its a bit of a bummer they miss your wedding, but between all the free stuff and the unexpecting places you run into them it is 100% worth it.
I picked Spacer, which was a complete mistake.
There isn't near as much content taking place in space, most of the action is happening planet side. And for the content that is in space, you don't need the additional O2 because you're usually working your way through tight corridors, potentially with a shotgun. Meanwhile when you are on a planet you are often traveling large distances across empty landscapes, a situation where you could really use the additional O2 to speed things up.
Anyway, Spacer is terrible and I think Terra Firma is a much better option.