I know we're living in the crapsack timeline, but I didn't realize it was a crapsack made of little shit people that the Republicans sculpted like they were Play-Doh and then threw them in the sack and made screaming noises, pretending the little shit people were screaming, before declaring that sack to be their new second-in-command after Trump.
Afaik it's not explicitly ruled out by the Constitution, though it's never been done. It would be very unorthodox, especially if the speaker were in prison.