OP might be confusing the adipartheos of Mary - the belief that she was a virgin before, during and after the birth of Christ. Some even go as so far as to imply Jesus wasn’t born like a human and emerged in some other way, which I’ll leave to the readers imagination.
452 is after 300 so that would be consistent with OP, however, here’s a “source” such as it is claiming her virginity in 150 AD https://en.m.wikipedia.org/wiki/Gospel_of_James
OP might be confusing the adipartheos of Mary - the belief that she was a virgin before, during and after the birth of Christ. Some even go as so far as to imply Jesus wasn’t born like a human and emerged in some other way, which I’ll leave to the readers imagination.