The amount of the investment is irrelevant, what’s important is the expected future return. Do you expect GME to increase faster than other options in some time frame? If not, sell it and invest in something with a higher expected return. Likewise for Bitcoin.

Whether something is currently up or down is irrelevant, as is the amount of your investment. The only relevant detail is the expected return and risk (variation) in the investment. Anything else is just gambling.