This strip is obviously done for laughs, but it is based on some serious questions.

Never mind language, timescale, or even being able to be in the same room without poisoning each other:

How would we communicate with intelligent alien life if their emotions and expressions are completely different than ours?

Some people were telling me about this event at some larger scifi conventions to simulate encounters:

One group would go off by themselves and invent an alien race, and the other group would be the human team to figure out how to communicate with the invented aliens.